Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 10/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 10/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 10/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061486 | 0.89 | GAA (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1637486 | 0.88 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3063801 | 0.86 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL13089094 | 0.80 | GAA (0.44) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3670338 | 0.79 | KCNA5 (0.44) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3063952 | 0.79 | HRH3 (0.41) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3060612 | 0.78 | SLC6A2 (0.46) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3021830 | 0.78 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1638361 | 0.77 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL23498050 | 0.77 | ADRA2A (0.94) | ADRA2AADRA2BADRA2CADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155715-B1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN INC (US) | 2013-03-13 | — | — | EP | disclosed |
| EP-2155715-B1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN INC (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | SINHA SANTOSH C | 2010-10-28 | — | — | US | disclosed |
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | SINHA SANTOSH C | 2010-10-28 | — | — | US | disclosed |
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | SINHA SANTOSH C | 2010-10-28 | — | — | US | disclosed |
| EP-2155715-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141312-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141312-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | ALLERGAN, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273814-A1 | ((PHENYL)IMIDAZOLYL)METHYLHETEROARYL COMPOUNDS | CYP11B2, TPMT, COXFA4L2 | ADRA2A 933/4885ADRA2B 710/4885ADRA2C 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.