Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.54 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 8/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29738820 | 0.76 | ALPL (0.48) | ALPLACLYALDH1A1SMN1; SMN2SGK1 | |
| SCHEMBL29114590 | 0.76 | ALPL (0.48) | ALPLACLYALDH1A1SMN1; SMN2SGK1 | |
| SCHEMBL22034348 | 0.75 | EDNRA (0.54) | ALPLEDNRAALDH1A1CCR4 | |
| SCHEMBL17001151 | 0.71 | CCR2 (0.57) | CCR2 | |
| SCHEMBL27561521 | 0.71 | ALPL (0.69) | ALPLACLYALDH1A1SMN1; SMN2SGK1 | |
| SCHEMBL320738 | 0.71 | SLC22A12 (0.56) | SGK1SCN9A | |
| SCHEMBL1094279 | 0.70 | SCN9A (0.57) | SCN9A | |
| SCHEMBL30479362 | 0.70 | USP2 (0.78) | SMN1; SMN2SCN9A | |
| SCHEMBL29668913 | 0.70 | SCN1A (0.63) | SCN9A | |
| SCHEMBL26567167 | 0.70 | CA12 (0.52) | ALPLACLYALDH1A1SGK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117062817-A | Pyrazolo [3,4-D ] pyrimidin-6-yl-sulfonamide derivatives for SGK-1 inhibition | 斯瑞福治疗股份有限公司 | 2023-11-14 | — | — | CN | disclosed |