Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3066001 | 0.96 | HRH3 (0.61) | HRH3KCNH2USP30 | |
| SCHEMBL9791042 | 0.83 | USP30 (0.56) | HRH3USP30 | |
| SCHEMBL2410805 | 0.83 | HRH3 (0.59) | HRH3KCNH2 | |
| SCHEMBL13178305 | 0.82 | HRH3 (0.46) | HRH3KCNH2USP30 | |
| SCHEMBL13178306 | 0.82 | HRH3 (0.46) | HRH3KCNH2USP30 | |
| SCHEMBL3047580 | 0.78 | HRH3 (0.72) | HRH3KCNH2USP30 | |
| SCHEMBL3053649 | 0.78 | HRH3 (0.72) | HRH3KCNH2USP30 | |
| SCHEMBL2412379 | 0.78 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL2411815 | 0.78 | HRH3 (0.55) | HRH3USP30 | |
| SCHEMBL2411817 | 0.78 | HRH3 (0.55) | HRH3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222358-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-09-02 | — | — | US | disclosed |
| US-20090105267-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES | ABBOTT LABORATORIES (US) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222358-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | HRH4, HRH2, TAC3 | HRH3 4/4885KCNH2 689/4885USP30 2843/4885 |
| US-20090105267-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES | TACR1, HTR3A, OPRM1 | HRH3 34/4885KCNH2 1067/4885USP30 3673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.