Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26684281 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AVCPALDH1A1KDM4E | |
| SCHEMBL3520908 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3520904 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2472101 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9351215 | 0.81 | NPFFR1 (0.58) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL9351222 | 0.81 | NPFFR1 (0.58) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2472098 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2474936 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28115143 | 0.79 | PLA2G7 (0.49) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1304439 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522608-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2025-03-19 | — | — | EP | disclosed |
| CN-119546602-A | Pyrrolidone derivatives as inhibitors of nfkb-induced kinase | 詹森药业有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |