Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520908 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL6070471 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL6070467 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL30667977 | 0.84 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL26684281 | 0.84 | SMN1; SMN2 (0.46) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL9351222 | 0.81 | NPFFR1 (0.58) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL9351215 | 0.81 | NPFFR1 (0.58) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2474936 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2472098 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2472101 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134401-B1 | ISOXAZOLINE HYDROXAMIC ACID DERIVATIVES AS LPXC INHIBITORS | NOVARTIS AG (CH) | 2018-06-13 | — | — | EP | disclosed |
| US-9718792-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-08-01 | — | — | US | disclosed |
| US-9718792-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-08-01 | — | — | US | disclosed |
| US-9718792-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-08-01 | — | — | US | disclosed |
| US-20170174640-A1 | ISOXAZOLINE HYDROXAMIC ACID DERIVATIVES AS LpxC INHIBITORS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-06-22 | — | — | US | disclosed |
| US-20170174640-A1 | ISOXAZOLINE HYDROXAMIC ACID DERIVATIVES AS LpxC INHIBITORS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-06-22 | — | — | US | disclosed |
| US-20170174640-A1 | ISOXAZOLINE HYDROXAMIC ACID DERIVATIVES AS LpxC INHIBITORS | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. | 2017-06-22 | — | — | US | disclosed |
| US-9637482-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-9637482-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-9637482-B2 | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors | NOVARTIS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-20030050288-A1 | Cyclic regimens utilizing indoline derivatives | WYETH | 2003-03-13 | — | — | US | disclosed |
| US-6462032-B1 | Cyclic regimens utilizing indoline derivatives | WYETH | 2002-10-08 | — | — | US | disclosed |
| US-20020086874-A1 | Indoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-07-04 | — | — | US | disclosed |
| CN-1350523-A | Indoline derivatives as progesterone antagonists | AMERICAN HOME PROD (US) | 2002-05-22 | — | — | CN | disclosed |
| US-6391907-B1 | ANTICANCER AGENTS; CONTRACEPTIVES | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| CN-1349416-A | Contraceptive compositions contaiing indoline derivatives and progestational agents | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| EP-1175398-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | American Home Products Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-1173212-A1 | CONTRACEPTIVE COMPOSITIONS CONTANING INDOLONE DERIVATIVES AND PROGESTATIONAL AGENTS | American Home Products Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066167-A1 | CONTRACEPTIVE COMPOSITIONS CONTAINING INDOLINE DERIVATIVES AND PROGESTATIONAL AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000066556-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086874-A1 | Indoline derivatives | PGR, GNRHR, PRLHR | ALDH1A1 1588/4885KDM4E 2337/4885L3MBTL1 3522/4885 |
| US-20170174640-A1 | ISOXAZOLINE HYDROXAMIC ACID DERIVATIVES AS LpxC INHIBITORS | PRXL2A, AGXT, HAX1 | ALDH1A1 2361/4885KDM4E 991/4885L3MBTL1 1967/4885 |
| US-20030050288-A1 | Cyclic regimens utilizing indoline derivatives | PRLHR, GNRHR, BRCA1 | ALDH1A1 1414/4885KDM4E 3104/4885L3MBTL1 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.