Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Sanguinarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.97 |
| ▸ | RAC1 | P63000 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | CDC42 | P60953 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | BAD | Q92934 | 7/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sanguinarium SCHEMBL43290 | 1.00 | RAC1 (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL3222766 | 0.99 | RAC1 (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8583232 | 0.99 | RAC1 (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL123241 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL29385229 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL23524622 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL30153784 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL30129850 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8584009 | 0.97 | BAD (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8937106 | 0.97 | BAD (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536665-A1 | NOVEL RAS INHIBITORS | KHR Biotec GmbH (DE) | 2025-04-16 | — | — | EP | disclosed |
| WO-2023242098-A1 | NOVEL RAS INHIBITORS | KHR Biotec GmbH (DE) | 2023-12-21 | — | — | WO | disclosed |