Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Sanguinarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.97 |
| ▸ | RAC1 | P63000 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | CDC42 | P60953 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 2/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | BAD | Q92934 | 7/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sanguinarium SCHEMBL30668087 | 1.00 | RAC1 (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL3222766 | 0.99 | RAC1 (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8583232 | 0.99 | RAC1 (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL123241 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL29385229 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL23524622 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL30153784 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL30129850 | 0.99 | BAD (1.00) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8584009 | 0.97 | BAD (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 | |
| Sanguinarium SCHEMBL8937106 | 0.97 | BAD (0.97) | RAC1ALDH1A1MAPTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3310 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122005564-A | Application of sanguinarine chloride in preparation of medicine for treating PRCC-TFE3 rearranged renal cell carcinoma | 南京鼓楼医院 | 2026-05-12 | — | — | CN | claimed |
| US-20260068884-A1 | COMPOSITION USED FOR KILLING FUNGI AND METHOD FOR APPLYING COMPOSITION | JIANGSU FLAG CHEMICAL INDUSTRY CO., LTD. (CN) | 2026-03-12 | — | — | US | claimed |
| EP-4581931-A1 | COMPOSITION USED FOR KILLING FUNGI AND METHOD FOR APPLYING COMPOSITION | Jiangsu Flag Chemical Industry Co., Ltd. (CN) | 2025-07-09 | — | — | EP | claimed |
| CN-119632949-A | Multifunctional composite sodium alginate microsphere and preparation method and application thereof | 长治医学院 | 2025-03-18 | — | — | CN | claimed |
| CN-114136941-B | SARM1 enzyme inhibitor and screening method and application thereof | 北京大学深圳研究生院 | 2024-04-16 | — | — | CN | claimed |
| EP-4335413-A2 | PROSTHETIC TISSUE VALVES | Cormatrix Cardiovascular, Inc. (US) | 2024-03-13 | — | — | EP | claimed |
| WO-2024046311-A1 | COMPOSITION USED FOR KILLING FUNGI AND METHOD FOR APPLYING COMPOSITION | 江苏中旗科技股份有限公司 | 2024-03-07 | — | — | WO | claimed |
| CN-117617257-A | Fungicidal compositions and methods of using the same | 江苏中旗科技股份有限公司 | 2024-03-01 | — | — | CN | claimed |
| WO-2023212179-A2 | THERAPEUTIC COMPOSITIONS FOR SKIN DISORDERS AND WOUND REPAIR | UNIVERSITY OF MIAMI (US) | 2023-11-02 | — | — | WO | claimed |
| CN-116908346-A | Method for measuring content of sanguinarine hydrochloride in children's white scallop cough syrup | 吉林草还丹药业有限公司 | 2023-10-20 | — | — | CN | claimed |
| EP-0527186-A1 | PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS | The Board of Trustees for the University of Illinois (US) | 1993-02-17 | — | — | EP | claimed |
| EP-0489743-A1 | INTRAGINGIVAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | VIPONT PHARMACEUTICAL, INC. (US) | 1992-06-17 | — | — | EP | claimed |
| WO-1992000718-A1 | INTRAGINGIVAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | VIPONT PHARMACEUTICAL, INC. (US) | 1992-01-23 | — | — | WO | claimed |
| WO-1991016820-A1 | PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 1991-11-14 | — | — | WO | claimed |
| US-4938763-A | DISSIPATION OF SOLVENT LEAVING WATER INSOLUBLE POLYMER; IMPLANTS; DRUG DELIVERY | ATRIX LABORATORIES, INC. | 1990-07-03 | — | — | US | claimed |
| US-4737503-A | BENZOPHENANTHRIDINE ALKALOID | VIPONT LABORATORIES, INC. (US) | 1988-04-12 | — | — | US | claimed |
| US-4689216-A | IMPROVED STABILITY | VIPONT LABORATORIES, INC. (US) | 1987-08-25 | — | — | US | claimed |
| US-4683133-A | PUMPING ALKALOID SALT SOLUTIONS ON GUMS | VIPONT LABORATORIES, INC. (US) | 1987-07-28 | — | — | US | claimed |
| US-4590061-A | BENZO-C-PHENANTHRIDINE ALKALOIDS | VIPONT LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | claimed |
| US-4517172-A | SANGUINARINE SALTS, ULTRAVILET LIGHT | VIPONT LABORATORIES, INC. (US) | 1985-05-14 | — | — | US | claimed |