Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065148 | 0.94 | CYP2D6 (0.43) | GAAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL13137615 | 0.87 | ACACB (0.43) | GAAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL13137566 | 0.81 | ACACB (0.44) | CYP2D6ALDH1A1PIN1 | |
| SCHEMBL2774280 | 0.73 | L3MBTL1 (0.45) | GAAMAPTMEN1KMT2ACYP2D6 | |
| SCHEMBL611943 | 0.66 | EPHX2 (0.50) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3067048 | 0.66 | L3MBTL1 (0.46) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL1313264 | 0.66 | CA1 (0.43) | MAPTCYP2D6LMNAKDM4EALDH1A1 | |
| SCHEMBL2841698 | 0.64 | KDM4E (0.45) | CYP2D6CYP3A4LMNAKDM4EALDH1A1 | |
| SCHEMBL5981219 | 0.64 | KMT2A (0.40) | GAAMAPTMEN1KMT2ALMNA | |
| SCHEMBL3465622 | 0.63 | PRKD3 (0.60) | GAAMAPTMEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222332-A1 | PYRAZOLO-PYRAZINES DERIVATIVES USED AS G PROTEIN INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222332-A1 | PYRAZOLO-PYRAZINES DERIVATIVES USED AS G PROTEIN INHIBITORS | GNAI1, GRK5, GNAI2 | GAA 4578/4885MAPT 3990/4885MEN1 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.