Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3067151 | 0.94 | GAA (0.45) | CYP2D6PIN1CNR1CNR2GAA | |
| SCHEMBL13137566 | 0.86 | ACACB (0.44) | CYP2D6PIN1ALDH1A1 | |
| SCHEMBL13137615 | 0.81 | ACACB (0.43) | CYP2D6PIN1CNR2GAAMAPT | |
| SCHEMBL1313264 | 0.72 | CA1 (0.43) | CYP2D6CREBBPMAPTLMNAALDH1A1 | |
| SCHEMBL3067048 | 0.72 | L3MBTL1 (0.46) | MAPTMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL2774280 | 0.66 | L3MBTL1 (0.45) | CYP2D6GAAMAPTMEN1CYP3A4 | |
| SCHEMBL5981219 | 0.65 | KMT2A (0.40) | GAAMAPTMEN1KMT2ANPC1 | |
| SCHEMBL20141716 | 0.65 | SMN1; SMN2 (0.60) | MAPTRAB9ALMNAALDH1A1POLB | |
| SCHEMBL8037981 | 0.65 | IDO1 (0.45) | PIN1NPC1RAB9A | |
| SCHEMBL1314087 | 0.65 | SMN1; SMN2 (0.47) | MAPTMEN1KMT2ARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222332-A1 | PYRAZOLO-PYRAZINES DERIVATIVES USED AS G PROTEIN INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222332-A1 | PYRAZOLO-PYRAZINES DERIVATIVES USED AS G PROTEIN INHIBITORS | GNAI1, GRK5, GNAI2 | CYP2D6 2844/4885PIN1 1779/4885CNR1 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.