GNAI1

Guanine nucleotide-binding protein G(i) subunit alpha-1 · P63096 · GNAI1 on Sugi Atlas →

58,370 patent compounds predicted against GNAI1, 33,241 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL293828 SCHEMBL293828 0.50 11/20
SCHEMBL151361 SCHEMBL151361 0.68 9/20
SCHEMBL249052 SCHEMBL249052 0.68 9/20
SCHEMBL11080 SCHEMBL11080 0.55 9/20
SCHEMBL337723 SCHEMBL337723 0.52 9/20
SCHEMBL293140 SCHEMBL293140 0.51 9/20
SCHEMBL162842 SCHEMBL162842 0.65 8/20
SCHEMBL44569 SCHEMBL44569 0.61 8/20
SCHEMBL10983 SCHEMBL10983 0.58 8/20
SCHEMBL294495 SCHEMBL294495 0.51 8/20
SCHEMBL10035 SCHEMBL10035 0.50 8/20
SCHEMBL180579 SCHEMBL180579 0.74 6/20
SCHEMBL250855 SCHEMBL250855 0.70 6/20
SCHEMBL107589 SCHEMBL107589 0.61 6/20
SCHEMBL11240 SCHEMBL11240 0.60 6/20
SCHEMBL27096 SCHEMBL27096 0.59 6/20
SCHEMBL165691 SCHEMBL165691 0.58 6/20
SCHEMBL294577 SCHEMBL294577 0.57 6/20
SCHEMBL44723 SCHEMBL44723 0.56 6/20
SCHEMBL347988 SCHEMBL347988 0.56 6/20

Clinical trials — most relevant to GNAI1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II PHASE2/PHASE3RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a) PHASE2NOT_YET_RECRUITING
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome PHASE1/PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. nanUNKNOWN
NGLY1 Natural History nanCOMPLETED
Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography nanACTIVE_NOT_RECRUITING
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Histamine Responsiveness in McCune-Albright Syndrome nanCOMPLETED
A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors nanWITHDRAWN
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity nanNOT_YET_RECRUITING
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Inherited Reproductive Disorders nanRECRUITING
Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia) nanUNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers nanCOMPLETED
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GNAI1 binder may also engage these)

ProteinNameSimilarity
Q5RAD4 1.000 Q5RAD4 →
GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-3 1.000 landscape →
Q60397 1.000 Q60397 →
P38402 1.000 P38402 →
Q9DC51 1.000 Q9DC51 →
P08752 1.000 P08752 →
P38401 1.000 P38401 →
P08753 1.000 P08753 →
P51876 1.000 P51876 →
P51877 1.000 P51877 →
Q4R592 1.000 Q4R592 →
P30682 1.000 P30682 →
O13055 1.000 O13055 →
P38403 1.000 P38403 →
P38400 1.000 P38400 →
P10825 1.000 P10825 →
GNAO1 Guanine nucleotide-binding protein G(o) subunit alpha 1.000 landscape →
P16378 1.000 P16378 →
P59216 1.000 P59216 →
P04897 1.000 P04897 →
GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 1.000 landscape →
P18872 1.000 P18872 →
Q00743 1.000 Q00743 →
P08239 1.000 P08239 →
P38404 1.000 P38404 →
P41776 1.000 P41776 →
P27045 1.000 P27045 →
P20353 1.000 P20353 →
P04696 1.000 P04696 →
Q3V3I2 1.000 Q3V3I2 →