Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29270817 | 1.00 | USP30 (0.36) | USP30HRH3CTSDBACE1CYP2C9 | |
| SCHEMBL29270849 | 0.86 | USP30 (0.34) | USP30CYP2C9CYP2C19KCNH2TPSAB1 | |
| SCHEMBL26961607 | 0.83 | PDE4B (0.34) | HRH3 | |
| SCHEMBL30675655 | 0.83 | PDE4B (0.34) | HRH3 | |
| SCHEMBL31628207 | 0.76 | GPR119 (0.35) | USP30CTSDBACE1 | |
| SCHEMBL31375547 | 0.76 | GPR119 (0.35) | USP30CTSDBACE1 | |
| SCHEMBL31628095 | 0.75 | GAA (0.36) | BDKRB1 | |
| SCHEMBL31628392 | 0.74 | HDAC6 (0.40) | BDKRB1 | |
| SCHEMBL31375533 | 0.74 | HDAC6 (0.40) | BDKRB1 | |
| SCHEMBL29270821 | 0.74 | XIAP (0.38) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |