Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | CTSD | P07339 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8800263 | 0.93 | POLB (0.46) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL8800068 | 0.93 | POLB (0.46) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL8800555 | 0.93 | POLB (0.46) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL30380124 | 0.92 | LMNA (0.49) | SMN1; SMN2POLBLMNAAKR1C3GBA2 | |
| SCHEMBL29812927 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL4599962 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL8799852 | 0.88 | POLB (0.46) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL8324568 | 0.87 | POLB (0.50) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL7838748 | 0.87 | POLB (0.45) | SMN1; SMN2POLBLMNAMEN1KMT2A | |
| SCHEMBL29655416 | 0.86 | LMNA (0.50) | SMN1; SMN2POLBLMNAGBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2023-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | C1R, F12, RDX | SMN1; SMN2 3449/4885POLB 2902/4885LMNA 1372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.