SCHEMBL30680337

SCHEMBL30680337

CC(C)(C)OC(=O)c1ccccc1NC(=O)C(Cc1ccccc1)NC(=O)C(=O)Nc1cc(Cl)ccc1CC1CC1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 5/20 0.40
CTSL P07711 3/20 0.39
YAP1 P46937 1/20 0.38
ATM Q13315 2/20 0.38
KMT2A Q03164 2/20 0.38
CTSS P25774 2/20 0.37
CTSB P07858 1/20 0.37
CTSK P43235 1/20 0.37
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29758151 0.88 CMA1 (0.40) USP30KMT2AMEN1
SCHEMBL30680292 0.85 PYGL (0.43) USP30CTSLKMT2ACTSSCTSB
SCHEMBL30680309 0.84 CTSL (0.46) USP30CTSLCTSSCTSBCTSK
SCHEMBL30680267 0.83 CTSL (0.40) USP30CTSLKMT2ACTSSCTSB
SCHEMBL30680256 0.81 CTSS (0.41) USP30CTSLKMT2ACTSSCTSB
SCHEMBL30680284 0.79 KMT2A (0.49) KMT2AMEN1
SCHEMBL30680293 0.79 MEN1 (0.41) USP30CTSLKMT2AMEN1
SCHEMBL30680260 0.77 CTSS (0.44) USP30CTSLCTSSCTSBCTSK
SCHEMBL30680264 0.77 NPC1 (0.42) KMT2AMEN1
SCHEMBL23486350 0.77 KLKB1 (0.43) USP30CTSLKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114728917-B Oxamide derivative, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2023-12-08 CN disclosed