Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 9/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533563 | 1.00 | PDE10A (0.60) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL8545852 | 0.86 | PDE10A (0.70) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL10265349 | 0.82 | PDE10A (0.74) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL2313999 | 0.82 | MAOA (0.55) | PDE10AKMT2ATSHRDHODHKDM4E | |
| SCHEMBL7248226 | 0.82 | KDM4E (0.70) | KMT2AHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL26617556 | 0.81 | PDE10A (0.62) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL27446591 | 0.81 | DHODH (0.54) | PDE10AKMT2ATSHRDHODHKDM4E | |
| SCHEMBL1264633 | 0.81 | PDE10A (0.62) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL27855178 | 0.79 | PDE10A (0.60) | PDE10AKMT2AHTTTSHRDHODH | |
| SCHEMBL26617708 | 0.78 | SMN1; SMN2 (0.58) | KMT2AHTTTSHRDHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4514789-A1 | <SUP2/>? <SUB2/>?V?BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA1.8 FOR THE TREATMENT OF PAIN | SiteOne Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| WO-2023211990-A1 | BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NA V1.8 FOR THE TREATMENT OF PAIN | SITEONE THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |