Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063443 | 0.98 | L3MBTL1 (0.62) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3081183 | 0.87 | L3MBTL1 (0.59) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3057279 | 0.86 | L3MBTL1 (0.58) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3067178 | 0.84 | L3MBTL1 (0.53) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3070448 | 0.83 | MAPT (0.54) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL27783371 | 0.81 | L3MBTL1 (0.50) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3075062 | 0.81 | L3MBTL1 (0.56) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL4770722 | 0.78 | L3MBTL1 (1.00) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL27783409 | 0.78 | L3MBTL1 (0.56) | L3MBTL1KEAP1NFE2L2SMN1; SMN2MAPT | |
| SCHEMBL3067306 | 0.78 | HSD11B1 (0.57) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790711-B2 | Inhibitors of 11β-Hydroxysteroid Dehydrogenase | HOFFMANN-LA ROCHE INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090023709-A1 | Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase | GILLESPIE PAUL | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023709-A1 | Inhibitors of 11B-Hyrdoxysteroid Dehydrogenase | HSD17B1, HSD17B2, HSD11B1 | L3MBTL1 3753/4885KEAP1 1004/4885NFE2L2 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.