Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26932126 | 1.00 | GABRA1 (0.36) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL30683043 | 0.89 | BRD4 (0.37) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL26932089 | 0.89 | GABRA1 (0.32) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL26932140 | 0.88 | PRMT5 (0.34) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL30683019 | 0.88 | PRMT5 (0.34) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL24838773 | 0.85 | GABRA1 (0.40) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL30683066 | 0.83 | AAK1 (0.39) | PDPK1PRMT5WDR77NAMPTL3MBTL1 | |
| SCHEMBL26931923 | 0.77 | EGLN1 (0.34) | — | |
| SCHEMBL30683085 | 0.76 | BRD4 (0.38) | PRMT5WDR77NAMPTL3MBTL1KDM4A | |
| SCHEMBL26932131 | 0.75 | EGLN1 (0.35) | GABRA1GABRA5GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |