Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 8/20 | 0.40 |
| ▸ | PPARD | Q03181 | 8/20 | 0.40 |
| ▸ | PPARA | Q07869 | 8/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26914037 | 0.86 | HTR6 (0.46) | KMT2APPARGPPARDPPARAHTR6 | |
| SCHEMBL26912756 | 0.83 | MEN1 (0.39) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL30684466 | 0.82 | SMN1; SMN2 (0.41) | KMT2APPARGPPARDPPARAHTR6 | |
| SCHEMBL26913617 | 0.81 | MEN1 (0.38) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL15374350 | 0.78 | MEN1 (0.46) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL15374349 | 0.76 | MEN1 (0.47) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL22990912 | 0.76 | HTR6 (0.51) | KMT2AMEN1PPARGPPARDPPARA | |
| SCHEMBL29783668 | 0.75 | HTR6 (0.53) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL20742940 | 0.75 | HTR6 (0.53) | KMT2AMEN1POLBPPARGPPARD | |
| SCHEMBL31497538 | 0.73 | NOD1 (0.40) | KMT2AMEN1POLBPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235809-A1 | CGAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-12-07 | — | — | WO | disclosed |
| US-20230391786-A1 | cGAS INHIBITORS | ELI LILLY AND COMPANY | 2023-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230391786-A1 | cGAS INHIBITORS | CGAS, STING1, TBK1 | KMT2A 4427/4885MEN1 2408/4885POLB 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.