Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.36 |
| ▸ | CGAS | Q8N884 | 2/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30684285 | 0.77 | CHUK (0.39) | CHUKROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26912433 | 0.76 | ROCK2 (0.40) | ROCK2ROCK1CDC42BPBCGAS | |
| SCHEMBL26912854 | 0.76 | CGAS (0.39) | ROCK2ROCK1CDC42BPBCDC42BPACGAS | |
| SCHEMBL26912510 | 0.76 | CGAS (0.35) | CHUKROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26912514 | 0.76 | CGAS (0.36) | ROCK2ROCK1CDC42BPBCDC42BPACGAS | |
| SCHEMBL26913132 | 0.76 | CGAS (0.36) | ROCK2ROCK1CDC42BPBCDC42BPACGAS | |
| Hydrochloric Acid SCHEMBL26913201 | 0.76 | CGAS (0.36) | ROCK2ROCK1CDC42BPBCDC42BPACGAS | |
| SCHEMBL26912804 | 0.76 | PGK1 (0.40) | ROCK2ROCK1CDC42BPBCDC42BPACGAS | |
| SCHEMBL26912568 | 0.75 | STK3 (0.39) | CHUKROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26912028 | 0.75 | LRRK2 (0.37) | ROCK2ROCK1CDC42BPBCDC42BPACGAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023235809-A1 | CGAS INHIBITORS | ELI LILLY AND COMPANY (US) | 2023-12-07 | — | — | WO | disclosed |