SCHEMBL30687

SCHEMBL30687

COc1ccc2nc(C(=O)c3ccc(F)c(O)c3)sc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 10/20 1.00
HSD17B2 P37059 10/20 1.00
CYP1A2 P05177 3/20 0.72
CYP3A4 P08684 3/20 0.72
CYP2C19 P33261 3/20 0.72
CYP2D6 P10635 2/20 0.72
CYP2C9 P11712 2/20 0.72
CYP2B6 P20813 2/20 0.72
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
SCD O00767 3/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
MAPT P10636 4/20 0.50
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
HTT P42858 1/20 0.47
DYRK1A Q13627 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30222 0.88 HSD17B1 (0.79) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL31410 0.85 HSD17B1 (0.73) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL30921 0.85 HSD17B1 (0.73) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL29673 0.84 HSD17B1 (1.00) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8404873 0.84 HSD17B1 (0.72) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL30246 0.82 HSD17B1 (0.69) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8402858 0.82 HSD17B1 (0.69) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8405370 0.81 HSD17B1 (0.74) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8403873 0.81 HSD17B1 (0.67) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19
SCHEMBL8405382 0.81 HSD17B1 (0.67) HSD17B1HSD17B2CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2609089-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2013-07-03 EP claimed
WO-2012025638-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2012-03-01 WO claimed
EP-2609089-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2013-07-03 EP disclosed
WO-2012025638-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2012-03-01 WO disclosed
WO-2012025638-A1 SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS Universität des Saarlandes (DE) 2012-03-01 WO disclosed