Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HRH2 | P25021 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051128 | 1.00 | LMNA (0.55) | LMNAPOLBGAAMAPTTSHR | |
| SCHEMBL306889 | 1.00 | LMNA (0.55) | LMNAPOLBGAAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL27632975 | 0.98 | LMNA (0.54) | LMNAPOLBGAAMAPTTSHR | |
| Bromide SCHEMBL1193429 | 0.98 | LMNA (0.54) | LMNAPOLBGAAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL942873 | 0.98 | LMNA (0.54) | LMNAPOLBGAAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL1032722 | 0.98 | LMNA (0.54) | LMNAPOLBGAAMAPTTSHR | |
| Bromide SCHEMBL16061698 | 0.96 | LMNA (0.53) | LMNAPOLBGAAMAPTTSHR | |
| Cadaverine Tartrate SCHEMBL3998786 | 0.85 | LMNA (0.47) | LMNAPOLBGAAMAPTTSHR | |
| Cadaverine Tartrate SCHEMBL28359878 | 0.85 | LMNA (0.47) | LMNAPOLBGAAMAPTTSHR | |
| Cadaverine Tartrate SCHEMBL307192 | 0.84 | LMNA (0.46) | LMNAPOLBGAAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 378 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239904-A | Chiral synthesis method of 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole optical isomer | 福建福瑞明德药业有限公司 | 2024-06-25 | — | — | CN | claimed |
| CN-117050033-A | Preparation method of pramipexole dihydrochloride related substances | 中国医学科学院药物研究所 | 2023-11-14 | — | — | CN | claimed |
| CN-116875980-A | Copper-reducing additive for HDI board and copper-reducing process | 上海天承化学有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-111187232-B | Method for synthesizing pramipexole dihydrochloride key intermediate by one-pot method | 润都制药(武汉)研究院有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-114249881-B | Solvent-free cashew phenol aldehyde amine epoxy resin curing agent containing thiazole structure and preparation method thereof | 浙江万盛股份有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-116422109-A | Self-extraction layered carbon dioxide trapping system and method | 嘉兴市碳捕手科技有限责任公司 | 2023-07-14 | — | — | CN | claimed |
| CN-115055066-B | Microporous polymer particle/polymer mixed matrix membrane and preparation method and application thereof | 南京工业大学 | 2023-07-07 | — | — | CN | claimed |
| CN-113636542-B | Method for preparing three-dimensional graphene from bottom to top | 广西大学 | 2023-01-10 | — | — | CN | claimed |
| CN-111072593-B | Preparation method of pramipexole dihydrochloride | 江苏天和制药有限公司 | 2022-11-08 | — | — | CN | claimed |
| CN-112608286-B | Preparation method of high-purity pramipexole | 广东红珊瑚药业有限公司 | 2022-09-30 | — | — | CN | claimed |
| EP-1761511-A1 | IMPROVED PROCESS FOR THE PREPARATION OF BIOLOGICALLY ACTIVE TETRAHYDROBENZTHIAZOLE DERIVATIVE | Alembic Limited (IN) | 2007-03-14 | — | — | EP | claimed |
| WO-2006070349-A2 | NOVEL PROCESS FOR PREPARING PRAMIPEXOLE AND ITS OPTICAL ISOMERIC MIXTURE BY REDUCTION WITH SODIUM TRIACETOXYBOROHYDRIDE | CHEMAGIS LTD. (IL) | 2006-07-06 | — | — | WO | claimed |
| US-20060148866-A1 | Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride | CHEMAGIS LTD. (IL) | 2006-07-06 | — | — | US | claimed |
| US-20060106224-A1 | Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates | MERCK DEVELOPMENT CENTRE PRIVATE LIMITED (IN) | 2006-05-18 | — | — | US | claimed |
| US-20060100256-A1 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole | CIPLA LIMITED (IN) | 2006-05-11 | — | — | US | claimed |
| WO-2006003677-A1 | IMPROVED PROCESS FOR THE PREPARATION OF BIOLOGICALLY ACTIVE TETRAHYDROBENZTHIAZOLE DERIVATIVE | ALEMBIC LIMITED (IN) | 2006-01-12 | — | — | WO | claimed |
| EP-1562921-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | Cipla Ltd. (IN) | 2005-08-17 | — | — | EP | claimed |
| EP-1542981-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-4,5,6,7-TETRAHYDRO-6-AMINOBENZOTHIAOLES FROM CYCLOHEXANES AND CYCLOHEXANONES AS INTERMEDIATES | Generics (UK) Limited (GB) | 2005-06-22 | — | — | EP | claimed |
| WO-2004041797-A1 | PROCESS FOR PREPARING 2,6-DIAMINO-4,5,6,7-TETRAHYDRO-BENZOTHIAZOLE | CIPLA LTD (IN) | 2004-05-21 | — | — | WO | claimed |
| WO-2004026850-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-4,5,6,7-TETRAHYDRO-6-AMINOBENZOTHIAOLES FROM CYCLOHEXANES AND CYCLOHEXANONES AS INTERMEDIATES | GENERICS [UK] LIMITED (GB) | 2004-04-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148866-A1 | Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride | DPP4, ACE, ALDH1A2 | LMNA 1778/4885POLB 1299/4885GAA 876/4885 |
| US-20060106224-A1 | Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates | CYP2J2, CYP4B1, CYP3A4 | LMNA 2095/4885POLB 1105/4885GAA 3348/4885 |
| US-20060100256-A1 | Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole | DNPEP, DDO, HNMT | LMNA 3980/4885POLB 323/4885GAA 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.