Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 9/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30699852 | 0.94 | MGLL (0.42) | MGLLRORCSLC9A1GPBAR1RBP4 | |
| SCHEMBL25326309 | 0.92 | MGLL (0.43) | MGLLPTGDR2GPR119 | |
| SCHEMBL30553203 | 0.86 | MGLL (0.43) | MGLLGPR119 | |
| SCHEMBL25325643 | 0.86 | MGLL (0.43) | MGLLGPR119 | |
| SCHEMBL30700524 | 0.86 | MGLL (0.41) | MGLL | |
| SCHEMBL30700591 | 0.85 | MGLL (0.40) | MGLL | |
| SCHEMBL30700467 | 0.85 | GPBAR1 (0.40) | MGLLGPR119GPBAR1 | |
| SCHEMBL30700062 | 0.84 | MGLL (0.41) | MGLL | |
| SCHEMBL30700150 | 0.84 | MGLL (0.35) | MGLLPIK3CDPIK3CAGPBAR1 | |
| SCHEMBL30700869 | 0.82 | MGLL (0.37) | MGLLPTGDR2GPR119GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |