Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CALCA | P06881 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.32 |
| ▸ | CDK9 | P50750 | 5/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700591 | 0.90 | MGLL (0.40) | MGLLPAK1 | |
| SCHEMBL30700887 | 0.89 | MGLL (0.40) | MGLLPAK1 | |
| SCHEMBL30700714 | 0.86 | MGLL (0.43) | MGLL | |
| SCHEMBL30699852 | 0.82 | MGLL (0.42) | MGLLGPBAR1 | |
| SCHEMBL30700116 | 0.82 | MGLL (0.42) | MGLLGPR119GPBAR1PTGDR2 | |
| SCHEMBL30700467 | 0.82 | GPBAR1 (0.40) | MGLLGPR119GPBAR1 | |
| SCHEMBL30700294 | 0.82 | MGLL (0.40) | MGLLPAK1CYP11B1CYP11B2 | |
| SCHEMBL25323946 | 0.82 | MGLL (0.42) | MGLLGPR119CYP11B1CYP11B2 | |
| SCHEMBL30700423 | 0.81 | MGLL (0.44) | MGLLPAK1 | |
| SCHEMBL30700280 | 0.81 | MGLL (0.37) | MGLLGPR119GPBAR1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |