Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 7/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700104 | 0.86 | KDM4E (0.42) | LMNAKDM4EABL1MGLLGAA | |
| SCHEMBL30700358 | 0.81 | MGLL (0.41) | MGLLKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL31549784 | 0.81 | MGLL (0.39) | LMNAKDM4EMGLLKCNQ3KCNQ2 | |
| SCHEMBL30775773 | 0.81 | MGLL (0.57) | MGLL | |
| SCHEMBL30700107 | 0.81 | ADRA2C (0.34) | MGLLPDK2 | |
| SCHEMBL30700434 | 0.81 | MGLL (0.40) | LMNAKDM4EABL1MGLLGAA | |
| SCHEMBL30700504 | 0.80 | MGLL (0.40) | LMNAKDM4EABL1MGLLGAA | |
| SCHEMBL25324389 | 0.79 | MGLL (0.43) | MGLLKCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL30700534 | 0.78 | MGLL (0.39) | LMNAKDM4EABL1MGLLGAA | |
| SCHEMBL30699945 | 0.78 | MGLL (0.45) | LMNAKDM4EABL1MGLLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |