Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30700280 | 0.90 | MGLL (0.37) | MGLLNAMPTCYP11B1CYP11B2 | |
| SCHEMBL30700373 | 0.87 | MGLL (0.43) | MGLLPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30700187 | 0.86 | MGLL (0.43) | MGLL | |
| SCHEMBL30700748 | 0.86 | MGLL (0.39) | MGLLBTK | |
| SCHEMBL30700274 | 0.85 | MGLL (0.41) | MGLLCYP11B1CYP11B2 | |
| SCHEMBL30700080 | 0.85 | MGLL (0.40) | MGLL | |
| SCHEMBL30700427 | 0.83 | MGLL (0.42) | MGLLNAMPTCYP11B1CYP11B2 | |
| SCHEMBL30700191 | 0.81 | CA2 (0.40) | MGLL | |
| SCHEMBL30700467 | 0.81 | GPBAR1 (0.40) | MGLLNAMPT | |
| SCHEMBL30700348 | 0.80 | MGLL (0.44) | MGLLCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543870-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2025-04-30 | — | — | EP | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |