Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.56 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 2/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16758967 | 0.87 | MGLL (0.54) | GPR119MGLLSTSKEAP1NFE2L2 | |
| SCHEMBL31071575 | 0.85 | GPR119 (0.53) | GPR119EPHX2STSTGFBR1MAPT | |
| SCHEMBL5534867 | 0.82 | CARM1 (0.55) | GPR119STSTGFBR1MAPTRORC | |
| SCHEMBL22462754 | 0.82 | GPR119 (0.58) | GPR119STSMRGPRX4MAPT | |
| SCHEMBL29716374 | 0.80 | GPR119 (0.56) | GPR119STS | |
| SCHEMBL19409580 | 0.78 | MGLL (0.46) | GPR119MGLLEPHX2STSTGFBR1 | |
| SCHEMBL13060199 | 0.78 | DPP4 (0.52) | GPR119MGLL | |
| SCHEMBL19409666 | 0.78 | IDO1 (0.43) | GPR119MGLLEPHX2MAPTRORC | |
| SCHEMBL25326239 | 0.76 | GPR119 (0.51) | GPR119EPHX2 | |
| SCHEMBL3922455 | 0.76 | GPR119 (0.69) | GPR119STSMAPTTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301113-A | Novel heterocyclic carbonyl cyclic compounds as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023247670-A1 | NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-12-28 | — | — | WO | disclosed |