SCHEMBL19409666

SCHEMBL19409666

CC(C)(C)OC(=O)N1CC(OCc2ccc(C(F)(F)F)cc2F)C1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.43
MGLL Q99685 1/20 0.43
RORC P51449 1/20 0.43
GPR119 Q8TDV5 2/20 0.42
TACR1 P25103 3/20 0.42
DPP4 P27487 1/20 0.41
MAPT P10636 1/20 0.41
ENPP2 Q13822 3/20 0.40
ATXN2 Q99700 3/20 0.40
PRMT5 O14744 1/20 0.40
WDR77 Q9BQA1 1/20 0.40
MC4R P32245 1/20 0.40
USP30 Q70CQ3 1/20 0.39
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
EPHX2 P34913 1/20 0.39
FFAR1 O14842 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19409580 0.90 MGLL (0.46) MGLLRORCGPR119TACR1MAPT
SCHEMBL25325007 0.87 PDE4B (0.42) MGLLRORCTACR1MAPTEPHX2
SCHEMBL30490318 0.86 ENPP2 (0.44) IDO1MGLLRORCGPR119TACR1
SCHEMBL29962387 0.86 IDO1 (0.42) IDO1RORCGPR119TACR1DPP4
SCHEMBL25325585 0.85 GPR119 (0.43) RORCGPR119DPP4PRMT5WDR77
SCHEMBL19411886 0.85 IDO1 (0.48) IDO1MGLLENPP2ATXN2CYP11B1
SCHEMBL22462872 0.85 IDO1 (0.41) IDO1RORCGPR119TACR1DPP4
SCHEMBL22462930 0.85 LIPE (0.46) GPR119DPP4ENPP2ATXN2EPHX2
SCHEMBL25326344 0.84 GPR119 (0.43) RORCGPR119DPP4PRMT5WDR77
SCHEMBL25300772 0.83 GPR119 (0.42) RORCGPR119DPP4PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025068347-A1 NEW HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2025-04-03 WO disclosed
US-11981661-B2 Heterocyclic compounds HOFFMANN-LA ROCHE INC. (US) 2024-05-14 US disclosed
EP-4208456-A1 HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2023-07-12 EP disclosed
US-20220267349-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2022-08-25 US disclosed
EP-4034541-A1 HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2022-08-03 EP disclosed
EP-4034239-A1 HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2022-08-03 EP disclosed
CN-114401969-A Heterocyclic compounds 豪夫迈·罗氏有限公司 2022-04-26 CN disclosed
US-20220106328-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2022-04-07 US disclosed
US-20220098176-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2022-03-31 US disclosed
US-20210107921-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2021-04-15 US disclosed
US-20210107921-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2021-04-15 US disclosed
WO-2021058416-A1 HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2021-04-01 WO disclosed
WO-2021058416-A1 HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2021-04-01 WO disclosed
US-20210094972-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2021-04-01 US disclosed
EP-3436444-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2020-05-13 EP disclosed
US-10323026-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-06-18 US disclosed
EP-3436444-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2019-02-06 EP disclosed
WO-2017171100-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-10-05 WO disclosed
US-20170283406-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210107921-A1 HETEROCYCLIC COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NQO1, CCNY IDO1 1210/4885MGLL 2899/4885RORC 2853/4885
US-20220098176-A1 HETEROCYCLIC COMPOUNDS CBR3, BRIX1, CCNY IDO1 1398/4885MGLL 996/4885RORC 1489/4885
US-11981661-B2 Heterocyclic compounds CBR3, BRIX1, CCNY IDO1 1398/4885MGLL 996/4885RORC 1489/4885
US-20220267349-A1 HETEROCYCLIC COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NQO1, CCNY IDO1 1210/4885MGLL 2899/4885RORC 2853/4885
US-20220106328-A1 HETEROCYCLIC COMPOUNDS CYP1B1, CYP4B1, CYP1A1 IDO1 797/4885MGLL 2162/4885RORC 1278/4885
US-20170283406-A1 HETEROCYCLIC COMPOUND MAG, HTT, ACHE IDO1 1695/4885MGLL 138/4885RORC 1963/4885
US-20210094972-A1 HETEROCYCLIC COMPOUNDS CYP1B1, CYP4B1, CYP1A1 IDO1 797/4885MGLL 2162/4885RORC 1278/4885
US-10323026-B2 Heterocyclic compound MAG, HTT, ACHE IDO1 1695/4885MGLL 138/4885RORC 1963/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.