Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227084 | 0.91 | NOS3 (0.35) | LMNASIGMAR1NOS3NOS1NOS2 | |
| SCHEMBL17580422 | 0.88 | — | — | |
| SCHEMBL29973340 | 0.75 | KEAP1 (0.40) | LMNASIGMAR1USP2ALDH1A1 | |
| SCHEMBL29181594 | 0.72 | — | — | |
| SCHEMBL20876924 | 0.71 | — | — | |
| SCHEMBL14760952 | 0.67 | — | — | |
| SCHEMBL29973217 | 0.66 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL3442415 | 0.65 | NOS3 (0.33) | LMNASIGMAR1NOS3NOS1NOS2 | |
| SCHEMBL30108218 | 0.65 | LMNA (0.33) | LMNASIGMAR1NOS3NOS1NOS2 | |
| SCHEMBL28959117 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114716366-B | 3-hydroxypyridin-4-one derivatives and application thereof in inhibiting iron death of renal cells | 浙江大学 | 2023-12-26 | — | — | CN | disclosed |