Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701921 | 1.00 | GPR119 (0.43) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL1781995 | 0.83 | USP30 (0.53) | GPR119PTPN2PTPN1PTPN6EGFR | |
| SCHEMBL30701907 | 0.81 | CCNC (0.51) | GPR119METDDB1CRBN | |
| SCHEMBL29945868 | 0.79 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL31466305 | 0.78 | HTT (0.44) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL24278460 | 0.77 | HTT (0.45) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL15950964 | 0.77 | GPR119 (0.50) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL1557907 | 0.76 | CTSD (0.49) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL1582522 | 0.76 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6HTT | |
| SCHEMBL27459322 | 0.76 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |