Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30701904 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL23411111 | 0.77 | TP53 (0.54) | MAPTMGLLMEN1KMT2AGPR119 | |
| SCHEMBL29967228 | 0.77 | TP53 (0.54) | MAPTMGLLMEN1KMT2AGPR119 | |
| SCHEMBL30701915 | 0.76 | INPPL1 (0.57) | MAPTKEAP1NFE2L2FAAHBTK | |
| SCHEMBL18176190 | 0.76 | MEN1 (0.57) | MAPTMGLLMEN1KMT2AGPR119 | |
| SCHEMBL7546740 | 0.75 | MAPT (0.51) | MAPTMEN1KMT2AKEAP1NFE2L2 | |
| SCHEMBL23411375 | 0.73 | GPR119 (0.62) | MAPTMGLLMEN1KMT2AGPR119 | |
| SCHEMBL29891976 | 0.73 | GPR119 (0.62) | MAPTMGLLMEN1KMT2AGPR119 | |
| SCHEMBL16827756 | 0.73 | MEN1 (0.48) | MAPTMGLLMEN1KMT2AFAAH | |
| SCHEMBL18418198 | 0.72 | MGLL (0.57) | MGLLMEN1KMT2AFAAHGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |