Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6553561 | 0.81 | CD274 (0.49) | KEAP1NFE2L2KMT2AMEN1GPR119 | |
| SCHEMBL6553567 | 0.80 | GPR119 (0.42) | MAPTKEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL30701904 | 0.79 | MAPT (0.47) | MAPTKEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL30701919 | 0.75 | MAPT (0.47) | MAPTKEAP1NFE2L2KMT2AMEN1 | |
| SCHEMBL11306145 | 0.74 | YAP1 (0.55) | STSNAMPTGPR119YAP1 | |
| SCHEMBL22391856 | 0.74 | BCL9 (0.46) | MAPTSTSGPR119TP53POLB | |
| SCHEMBL3172041 | 0.74 | MAPT (0.57) | MAPTKEAP1NFE2L2STSKMT2A | |
| SCHEMBL30563607 | 0.73 | GPR119 (0.65) | MAPTSTSKMT2AMEN1LMNA | |
| SCHEMBL8702039 | 0.73 | GPR119 (0.45) | MAPTKEAP1NFE2L2STSKMT2A | |
| SCHEMBL7434625 | 0.73 | YAP1 (0.58) | STSKMT2AMEN1GPR119YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859607-B1 | GUANIDINO PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0859607-A4 | GUANIDINO PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0859607-A1 | GUANIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997011693-A1 | GUANIDINO PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-04-03 | — | — | WO | disclosed |