Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | GRM5 | P41594 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | AGXT | P21549 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31159974 | 0.81 | NPC1 (0.68) | NPC1ALDH1A1CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL22290322 | 0.80 | NPC1 (0.58) | NPC1ALDH1A1CYP2D6CYP2C19IDO1 | |
| SCHEMBL27479330 | 0.80 | CYP2D6 (0.58) | NPC1ALDH1A1CYP2D6CYP2C19MAOB | |
| SCHEMBL31173205 | 0.80 | NPC1 (0.58) | NPC1ALDH1A1CYP2D6CYP2C19IDO1 | |
| SCHEMBL14611352 | 0.80 | CYP2D6 (0.58) | NPC1ALDH1A1CYP2D6CYP2C19IDO1 | |
| SCHEMBL13933221 | 0.80 | ALDH1A1 (0.58) | NPC1ALDH1A1CYP2D6CYP2C19GRM5 | |
| SCHEMBL223680 | 0.80 | ALDH1A1 (0.61) | NPC1ALDH1A1CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL29816629 | 0.80 | ALDH1A1 (0.61) | NPC1ALDH1A1CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL30931656 | 0.78 | MAOB (0.61) | GRM5CYP3A4IDO1AGXTMAOB | |
| SCHEMBL10055039 | 0.78 | NPC1 (0.68) | NPC1ALDH1A1CYP2D6CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554936-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | The Trustees of Indiana University (US) | 2025-05-21 | — | — | EP | disclosed |
| WO-2024015759-A1 | CRIZOTINIB ANALOGUES AS SHIP1 INHIBITORS USEFUL TO TREAT ALZHEINER'S DISEASES | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-18 | — | — | WO | disclosed |