Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070374 | 1.00 | CYP1A2 (0.47) | CYP1A2KMT2ATDP1ALDH1A1GLA | |
| SCHEMBL11988772 | 1.00 | CYP1A2 (0.47) | CYP1A2KMT2ATDP1ALDH1A1GLA | |
| SCHEMBL25159581 | 0.83 | MEN1 (0.51) | CYP1A2KMT2AALDH1A1GLATSHR | |
| SCHEMBL28319517 | 0.83 | MEN1 (0.51) | CYP1A2KMT2AALDH1A1GLATSHR | |
| SCHEMBL31436287 | 0.83 | TDP1 (0.45) | CYP1A2KMT2ATDP1ALDH1A1GLA | |
| SCHEMBL31376537 | 0.83 | TDP1 (0.45) | CYP1A2KMT2ATDP1ALDH1A1GLA | |
| SCHEMBL11584234 | 0.82 | TDP1 (0.50) | CYP1A2KMT2ATDP1ALDH1A1GLA | |
| SCHEMBL27503595 | 0.81 | KMT2A (0.50) | KMT2ATDP1ALDH1A1GLATSHR | |
| SCHEMBL29204497 | 0.81 | KDM4E (0.51) | ALDH1A1CYP3A4MAPTCYP2C9CYP2C19 | |
| SCHEMBL13952525 | 0.81 | TDP1 (0.49) | CYP1A2KMT2ATDP1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247448-B2 | Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2012-08-21 | — | — | US | disclosed |
| US-7820847-B2 | Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2010-10-26 | — | — | US | disclosed |
| US-20100261789-A1 | Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes | ZEILLER JEAN-JACQUES | 2010-10-14 | — | — | US | disclosed |
| US-20060178434-A1 | Butenoic acid derivatives processes for the preparation thereof pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2006-08-10 | — | — | US | disclosed |
| US-4963578-A | LEUKOTRIN ANTAGONISTS; ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1990-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261789-A1 | Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes | ALOX15, LIPA, APOB | CYP1A2 369/4885KMT2A 4767/4885TDP1 2708/4885 |
| US-20060178434-A1 | Butenoic acid derivatives processes for the preparation thereof pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia atherosclerosis and diabetes | APOB, ALOX15, GPR119 | CYP1A2 414/4885KMT2A 4790/4885TDP1 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.