Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22509160 | 1.00 | GSK3B (0.46) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL22509195 | 0.88 | GSK3B (0.44) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL30705248 | 0.88 | GSK3B (0.44) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL24240371 | 0.86 | GSK3B (0.34) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL22509188 | 0.83 | GSK3B (0.49) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL30705252 | 0.83 | GSK3B (0.49) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL29025136 | 0.82 | KDM4E (0.47) | GSK3BPIM1CDK9CDK5CDK2 | |
| SCHEMBL30337440 | 0.81 | GSK3B (0.54) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL17490446 | 0.81 | GSK3B (0.54) | GSK3BJAK2AURKAPAK4ABL1 | |
| SCHEMBL30957637 | 0.79 | PDK1 (0.50) | GSK3BJAK2AURKAPAK4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747950-B | Pyrimidine derivatives for the treatment of cancer | 深圳福沃药业有限公司 | 2024-01-23 | — | — | CN | disclosed |