SCHEMBL30709648

SCHEMBL30709648

N#Cc1cccc(-c2ncccc2F)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.46
BCAT1 P54687 1/20 0.43
CYP11B2 P19099 2/20 0.41
LRRK2 Q5S007 4/20 0.40
ADORA2B P29275 2/20 0.38
GABRG2 P18507 3/20 0.37
GABRB3 P28472 3/20 0.37
GABRA5 P31644 3/20 0.37
GABRA3 P34903 3/20 0.37
TGFBR1 P36897 1/20 0.37
GABRA1 P14867 2/20 0.36
EGLN2 Q96KS0 1/20 0.36
CYP11B1 P15538 1/20 0.36
CNR2 P34972 1/20 0.35
TDP2 O95551 1/20 0.35
NSD2 O96028 1/20 0.35
ABL1 P00519 1/20 0.35
PLCG1 P19174 1/20 0.35
CES1 P23141 1/20 0.35
PAX8 Q06710 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26185770 1.00 ADORA2A (0.46) ADORA2ABCAT1CYP11B2LRRK2ADORA2B
SCHEMBL3292813 0.87 BCAT1 (0.50) ADORA2ABCAT1CYP11B2LRRK2GABRG2
SCHEMBL29496944 0.84 ADORA2A (0.50) ADORA2ABCAT1CYP11B2LRRK2ADORA2B
SCHEMBL3296198 0.80 CHUK (0.45) ADORA2ABCAT1CYP11B2ADORA2BGABRG2
SCHEMBL21596836 0.80 LRRK2 (0.43) ADORA2ABCAT1CYP11B2LRRK2ADORA2B
SCHEMBL19072702 0.77 GABRG2 (0.39) ADORA2ACYP11B2ADORA2BGABRG2GABRB3
SCHEMBL2652445 0.76 CYP11B2 (0.40) ADORA2ACYP11B2GABRG2GABRB3GABRA5
SCHEMBL30814370 0.75 GRIA1 (0.43) ADORA2ABCAT1CYP11B2LRRK2ADORA2B
SCHEMBL28856972 0.75 GRIA1 (0.43) ADORA2ABCAT1CYP11B2LRRK2ADORA2B
SCHEMBL12480391 0.75 GABRG2 (0.43) GABRG2GABRB3GABRA5GABRA3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116903668-A Organic electroluminescent material and device 环球展览公司 2023-10-20 CN disclosed