Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207612 | 0.82 | NOS3 (0.52) | PKMRAD52MAPK10MAPK14NOS3 | |
| SCHEMBL29498353 | 0.82 | NOS3 (0.52) | PKMRAD52MAPK10MAPK14NOS3 | |
| SCHEMBL29405492 | 0.76 | MAOA (0.50) | TDP1L3MBTL1MAPK10MAPK14NOS3 | |
| SCHEMBL1009165 | 0.76 | MAOA (0.50) | TDP1L3MBTL1MAPK10MAPK14NOS3 | |
| SCHEMBL2226165 | 0.76 | NOS3 (0.45) | PKMRAD52MAPK10MAPK14GABRA1 | |
| SCHEMBL6986806 | 0.73 | MAOA (0.40) | TDP1L3MBTL1PKMRAD52MAPK10 | |
| SCHEMBL6983460 | 0.72 | MAOA (0.39) | TDP1L3MBTL1PKMRAD52MAPK10 | |
| SCHEMBL13069277 | 0.69 | PTPRC (0.47) | TDP1L3MBTL1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL1973786 | 0.69 | NOS3 (0.52) | TDP1L3MBTL1PKMRAD52MAPK10 | |
| SCHEMBL5778545 | 0.69 | PLAU (0.44) | TDP1L3MBTL1MAPK10MAPK14TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |