Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19410203 | 1.00 | PLA2G2A (0.48) | PLA2G2ASYKMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL19410201 | 1.00 | PLA2G2A (0.48) | PLA2G2ASYKMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL19427003 | 0.91 | PLA2G2A (0.46) | PLA2G2ASYKMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL31369413 | 0.87 | PLA2G2A (0.52) | PLA2G2ASYKMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL25798337 | 0.84 | MAPT (0.39) | SYKALDH1A1MAPTRECQLSCN9A | |
| SCHEMBL16099676 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRMAPTRECQL | |
| SCHEMBL30343690 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRMAPTRECQL | |
| SCHEMBL7434865 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRMAPTRECQL | |
| SCHEMBL30002479 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRMAPTRECQL | |
| SCHEMBL16099677 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440097-B1 | MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80/PD-L1 PROTEIN/PROTEIN INTERACTIONS | BRISTOL MYERS SQUIBB CO (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-110997698-B | Immunomodulatory agents acting as PD-1 antagonists | 百时美施贵宝公司 | 2023-12-26 | — | — | CN | disclosed |