Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 19/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29303097 | 1.00 | KLKB1 (0.39) | KLKB1METTL3 | |
| SCHEMBL24738256 | 0.87 | KLKB1 (0.38) | KLKB1METTL3 | |
| SCHEMBL29302762 | 0.83 | GRM5 (0.44) | — | |
| SCHEMBL24738255 | 0.83 | KLKB1 (0.39) | KLKB1METTL3 | |
| SCHEMBL29137065 | 0.78 | KLKB1 (0.44) | KLKB1METTL3 | |
| SCHEMBL27033743 | 0.78 | KLKB1 (0.40) | KLKB1METTL3 | |
| SCHEMBL29958329 | 0.78 | SMN1; SMN2 (0.42) | KLKB1METTL3 | |
| SCHEMBL27033446 | 0.78 | METTL3 (0.41) | KLKB1METTL3 | |
| SCHEMBL29957846 | 0.78 | METTL3 (0.41) | KLKB1METTL3 | |
| SCHEMBL24737797 | 0.77 | SCN9A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-11 | — | — | US | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228488-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | KLKB1 1/4885METTL3 4596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.