Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 16/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30711687 | 0.87 | KLKB1 (0.39) | KLKB1METTL3 | |
| SCHEMBL29303097 | 0.87 | KLKB1 (0.39) | KLKB1METTL3 | |
| SCHEMBL24729569 | 0.84 | METTL3 (0.39) | KLKB1METTL3KDM4ENPC1RAB9A | |
| SCHEMBL27033743 | 0.83 | KLKB1 (0.40) | KLKB1METTL3 | |
| SCHEMBL24738255 | 0.83 | KLKB1 (0.39) | KLKB1METTL3 | |
| SCHEMBL24738251 | 0.78 | METTL3 (0.43) | KLKB1METTL3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29958329 | 0.78 | SMN1; SMN2 (0.42) | KLKB1METTL3KDM4ENPC1RAB9A | |
| SCHEMBL24738257 | 0.78 | METTL3 (0.39) | KLKB1METTL3 | |
| SCHEMBL24729570 | 0.76 | SMN1; SMN2 (0.41) | KLKB1METTL3KDM4ENPC1RAB9A | |
| SCHEMBL24729661 | 0.76 | SMN1; SMN2 (0.46) | KLKB1METTL3KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |