Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041061 | 0.86 | HTR2A (0.56) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL30340615 | 0.85 | ALDH1A1 (0.56) | HTR2AHTR2CPOLBALDH1A1GAA | |
| SCHEMBL12919994 | 0.85 | HTR2A (0.53) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL11681398 | 0.84 | CREBBP (0.43) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL8905312 | 0.84 | HTR2A (0.53) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL8909599 | 0.83 | HTR2A (0.52) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL19193260 | 0.82 | HTR2A (0.51) | HTR2AHTR2CNPSR1POLBALDH1A1 | |
| SCHEMBL8905316 | 0.80 | HTR2A (0.49) | HTR2AHTR2CPOLBALDH1A1GAA | |
| SCHEMBL16284298 | 0.80 | HTR2A (0.46) | HTR2AHTR2CNPSR1ALDH1A1LMNA | |
| SCHEMBL28348323 | 0.80 | HTR2A (0.50) | HTR2AHTR2CNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028350-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | AFFYMETRIX, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028350-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | AFFYMETRIX, INC. (US) | 2011-02-03 | — | — | US | disclosed |
| US-20100324266-A1 | Photocleavable Protecting Groups | AFFYMETRIX, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-7834049-B2 | Sulfonamide compound for treating arteriosclerosis, psoriasis, colon cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20100267754-A1 | INTEGRIN EXPRESSION INHIBITOR | WAKABAYASHI TOSHIAKI | 2010-10-21 | — | — | US | disclosed |
| US-20090076295-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | AFFYMETRIX, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| US-20050176712-A1 | Integrin expression inhibitor | EISAI CO., LTD. | 2005-08-11 | — | — | US | disclosed |
| US-20040018192-A1 | Integrin expression inhibitors | EISAI CO., LTD. (JP) | 2004-01-29 | — | — | US | disclosed |
| EP-0673937-B1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | EISAI CO LTD (JP) | 2003-11-26 | — | — | EP | disclosed |
| EP-1258252-A1 | INTEGRIN EXPRESSION INHIBITORS | Eisai Co., Ltd. (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5550134-A | ADMINISTERING TO A MAMMAL FROM A SERIES OF BENZOQUINOLIN-3-ONE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5512590-A | PREVENTS DISORDER OF GABAERGIC TRANSMISSION | SYNTHELABO (FR) | 1996-04-30 | — | — | US | disclosed |
| EP-0682025-A1 | 5,6-dihydro-4H-imidazo 2',1':2,3 imidazo 4,5,1-ij quinoline and 4,5-dihydroimidazo 1,2-a pyrrolo 1,2,3-cd benzimidazol derivatives | SYNTHELABO (FR) | 1995-11-15 | — | — | EP | disclosed |
| EP-0673937-A1 | BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5436250-A | Isatineoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1995-07-25 | — | — | US | disclosed |
| US-5242912-A | Treatment of autoimmune and rheumatic diseases and osteoporosis | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| US-5242918-A | Isatinoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-07 | — | — | US | disclosed |
| WO-1993005043-A1 | NOVEL ISATINOXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1993-03-18 | — | — | WO | disclosed |
| EP-0529636-A1 | Novel isatinoxime derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-03 | — | — | EP | disclosed |
| EP-0434844-A1 | NEW CYCLIC ANTHRANILIC ACID DERIVATIVE AND METHOD OF PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1991-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176712-A1 | Integrin expression inhibitor | ITGB5, ITGB1, ITGB2 | HTR2A 3900/4885HTR2C 4234/4885NPSR1 1290/4885 |
| US-20100324266-A1 | Photocleavable Protecting Groups | POLL, PCNA, ERCC4 | HTR2A 4378/4885HTR2C 4463/4885NPSR1 2958/4885 |
| US-20090076295-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | POLL, PCNA, ERCC4 | HTR2A 4378/4885HTR2C 4463/4885NPSR1 2958/4885 |
| US-20100267754-A1 | INTEGRIN EXPRESSION INHIBITOR | ITGB5, ITGB1, ITGB2 | HTR2A 3900/4885HTR2C 4234/4885NPSR1 1290/4885 |
| US-20040018192-A1 | Integrin expression inhibitors | ITGB1, ITGB4, ITGB5 | HTR2A 4343/4885HTR2C 4423/4885NPSR1 2221/4885 |
| US-20110028350-A1 | PHOTOCLEAVABLE PROTECTING GROUPS | POLL, ERCC5, FBL | HTR2A 4421/4885HTR2C 4388/4885NPSR1 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.