Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.61 |
| ▸ | TGM2 | P21980 | 10/20 | 0.48 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740595 | 1.00 | CES1 (0.61) | CES1TGM2GALR3PBRM1IDO1 | |
| SCHEMBL5741222 | 0.81 | POLB (0.51) | CES1PBRM1IDO1 | |
| SCHEMBL5752424 | 0.79 | CES1 (0.61) | CES1TGM2GALR3IDO1 | |
| SCHEMBL282066 | 0.76 | CES1 (1.00) | CES1TGM2PBRM1 | |
| SCHEMBL30716604 | 0.76 | CES1 (1.00) | CES1TGM2PBRM1 | |
| SCHEMBL5740135 | 0.75 | CES1 (0.58) | CES1TGM2 | |
| Nitrogen SCHEMBL29242307 | 0.73 | CES1 (0.92) | CES1TGM2PBRM1 | |
| SCHEMBL11530748 | 0.72 | CES1 (0.61) | CES1TGM2GALR3IDO1 | |
| SCHEMBL5988948 | 0.72 | CES1 (0.61) | CES1TGM2GALR3IDO1 | |
| SCHEMBL5989290 | 0.72 | LRRK2 (0.50) | GALR3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| EP-0155828-B1 | PROCESS FOR MAKING 2-OXINDOLE-1-CARBOXAMIDES AND INTERMEDIATES THEREFOR | PFIZER INC. (US) | 1990-09-19 | — | — | EP | disclosed |
| CN-1009197-B | Process for preparing N, 3-disubstituted 2-oxindole-1-carboxamides | PFIZER (US) | 1990-08-15 | — | — | CN | disclosed |
| EP-0244918-B1 | SUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDE INTERMEDIATES | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |
| EP-0156603-B1 | 3-SUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-08-23 | — | — | EP | disclosed |
| EP-0164860-B1 | N,3-DISUBSTITUTED 2-OXINDOLE-1-CARBOXAMIDES AS ANALGESIC AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-07-05 | — | — | EP | disclosed |
| EP-0175551-B1 | ANALGESIC AND ANTIINFLAMMATORY 1,3-DIACYL-2-OXINDOLE COMPOUNDS | PFIZER INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| EP-0153818-B1 | 1,3-DISUBSTITUTED 2-OXINDOLES AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS | PFIZER INC. (US) | 1989-03-15 | — | — | EP | disclosed |
| US-4808601-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1989-02-28 | — | — | US | disclosed |
| US-4791129-A | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4652658-A | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0208510-A2 | 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents | PFIZER INC. (US) | 1987-01-14 | — | — | EP | disclosed |
| CN-86105309-A | Oxindole-3-carbonyl amines the compound that replaces as the 1-of anti-inflammatory and anodyne | — | 1987-01-14 | — | — | CN | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| EP-0164860-A1 | N,3-disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1985-12-18 | — | — | EP | disclosed |
| US-4556672-A | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0156603-A2 | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0155828-A2 | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0153818-A2 | 1,3-Disubstituted 2-oxindoles as analgesic and anti-inflammatory agents | PFIZER INC. (US) | 1985-09-04 | — | — | EP | disclosed |