Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 12/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27297561 | 1.00 | JAK1 (0.40) | JAK1JAK3JAK2BTKNLRP3 | |
| SCHEMBL30718302 | 0.92 | JAK1 (0.38) | JAK1JAK3JAK2BTKNLRP3 | |
| SCHEMBL30718306 | 0.92 | JAK1 (0.38) | JAK1JAK3JAK2BTKNLRP3 | |
| SCHEMBL27289322 | 0.82 | NLRP3 (0.38) | NLRP3CHEK2IKBKB | |
| SCHEMBL30718299 | 0.81 | JAK1 (0.40) | JAK1JAK3JAK2BTK | |
| SCHEMBL27289337 | 0.79 | JAK1 (0.41) | JAK1JAK3JAK2NLRP3TYK2 | |
| SCHEMBL27289118 | 0.78 | NLRP3 (0.55) | NLRP3CHEK2 | |
| SCHEMBL30718319 | 0.77 | JAK1 (0.40) | JAK1JAK3JAK2BTK | |
| SCHEMBL26772151 | 0.77 | CHRM1 (0.47) | NLRP3IKBKB | |
| SCHEMBL24840762 | 0.77 | NLRP3 (0.51) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006559-A1 | MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS | Neumora Therapeutics, Inc. (US) | 2024-01-04 | — | — | WO | disclosed |