Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 9/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27143890 | 1.00 | SHMT2 (0.56) | SHMT2GAAPIK3CAPIK3CGALDH3A1 | |
| SCHEMBL27143319 | 0.87 | SHMT2 (0.53) | SHMT2GAAPIM1PIM2ATR | |
| SCHEMBL30718760 | 0.87 | SHMT2 (0.53) | SHMT2GAAPIM1PIM2ATR | |
| SCHEMBL31623149 | 0.82 | SHMT2 (0.47) | SHMT2GAASMN1; SMN2 | |
| SCHEMBL30718774 | 0.80 | SHMT2 (0.56) | SHMT2GAAPIM1ATRATRIP | |
| SCHEMBL27140115 | 0.80 | SHMT2 (0.56) | SHMT2GAAPIM1ATRATRIP | |
| SCHEMBL27138757 | 0.77 | ALDH3A1 (0.51) | GAAPIK3CAPIK3CGALDH3A1ALDH1A3 | |
| SCHEMBL31623217 | 0.75 | KDM4E (0.39) | PIK3CAPIK3CGALDH3A1ALDH1A3CNR2 | |
| SCHEMBL30718852 | 0.74 | SHMT2 (0.39) | SHMT2PIK3CACNR2 | |
| SCHEMBL27142724 | 0.74 | SHMT2 (0.39) | SHMT2PIK3CACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547658-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | Bristol-Myers Squibb Company (US) | 2025-05-07 | — | — | EP | disclosed |
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |