Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8864708 | 1.00 | KDM4E (0.72) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL12372657 | 0.84 | POLB (0.64) | KDM4ELMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8224982 | 0.84 | HPGD (0.74) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL5195982 | 0.84 | KDM4E (0.57) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL1785806 | 0.84 | KDM4E (0.57) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL20682180 | 0.83 | POLB (0.62) | KDM4ELMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8864677 | 0.83 | HPGD (0.70) | ALDH1A1HPGDSMN1; SMN2MAPK1MAPT | |
| SCHEMBL8864802 | 0.81 | HPGD (0.67) | LMNAALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL29382447 | 0.81 | SMN1; SMN2 (0.70) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL8865071 | 0.81 | HPGD (0.67) | KDM4EALDH1A1TP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |