Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.58 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30719611 | 1.00 | KDM4E (0.72) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL12372657 | 0.84 | POLB (0.64) | KDM4ELMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8224982 | 0.84 | HPGD (0.74) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL5195982 | 0.84 | KDM4E (0.57) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL1785806 | 0.84 | KDM4E (0.57) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL20682180 | 0.83 | POLB (0.62) | KDM4ELMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8864677 | 0.83 | HPGD (0.70) | ALDH1A1HPGDSMN1; SMN2MAPK1MAPT | |
| SCHEMBL8864802 | 0.81 | HPGD (0.67) | LMNAALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL29382447 | 0.81 | SMN1; SMN2 (0.70) | KDM4ELMNAALDH1A1TP53HPGD | |
| SCHEMBL8865071 | 0.81 | HPGD (0.67) | KDM4EALDH1A1TP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230132035-A1 | Toll-Like Receptor 8 (TLR8)-Specific Antagonists and Methods of Making and Uses Thereof | UNIV COLORADO REGENTS (US) | 2023-04-27 | — | — | US | disclosed |
| US-11466010-B2 | Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2022-10-11 | — | — | US | disclosed |
| US-20210179621-A1 | Toll-Like Receptor 8 (TLR8) Specific Antagonists and Methods of Making and Uses Thereof | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2021-06-17 | — | — | US | disclosed |
| US-10364352-B2 | High temperature melt processable semi-crystalline poly(aryl ether ketone) containing a (4-hydroxyphenyl)phthalazin-1(2h)-one comonomer unit | POLYMICS, LTD (US) | 2019-07-30 | — | — | US | disclosed |
| US-10189991-B2 | High temperature melt processable semi-crystalline poly (aryl ether ketone) containing a (4-hydroxyphenyl) phthalazin-1 (2H)-one comonomer unit | POLYMICS, LTD (US) | 2019-01-29 | — | — | US | disclosed |
| EP-2346921-B1 | HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1(2H)-ONE COMONOMER UNIT | POLYMICS LTD (US) | 2019-01-02 | — | — | EP | disclosed |
| EP-2493981-B1 | HIGH TEMPERATURE POLYMER BLENDS OF POLY(ARYL ETHER KETONE PHTHALAZINONE) | POLYMICS LTD (US) | 2018-06-20 | — | — | EP | disclosed |
| US-20150252189-A1 | HIGH TEMPERATURE POLYMER BLENDS OF POLY(ARYL ETHER KETONE PHTHALAZINONE) | POLYMICS LTD (US) | 2015-09-10 | — | — | US | disclosed |
| US-20150252189-A1 | HIGH TEMPERATURE POLYMER BLENDS OF POLY(ARYL ETHER KETONE PHTHALAZINONE) | POLYMICS LTD (US) | 2015-09-10 | — | — | US | disclosed |
| US-20150183934-A1 | HIGH TEMPERATURE POLY(ARYL ETHER)S CONTAINING A PHTHALAZINONE MOIETY | POLYMICS, LTD. | 2015-07-02 | — | — | US | disclosed |
| WO-2010062361-A1 | HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1(2H)-ONE COMONOMER UNIT | POLYMICS, LTD (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20100113688-A1 | High temperature melt processable semi-crystalline poly (aryl ether ketone) containing a (4-hydroxyphenyl) phthalazin-1 (2H)-one comonomer unit | POLYMICS, LTD. | 2010-05-06 | — | — | US | disclosed |
| US-20100113688-A1 | High temperature melt processable semi-crystalline poly (aryl ether ketone) containing a (4-hydroxyphenyl) phthalazin-1 (2H)-one comonomer unit | POLYMICS, LTD. | 2010-05-06 | — | — | US | disclosed |
| WO-2009039606-A1 | HIGH TEMPERATURE POLY(ARYL ETHER)S CONTAINING A PHTHALAZINONE MOIETY | HT MATERIALS CORPORATION (US) | 2009-04-02 | — | — | WO | disclosed |
| US-20070238853-A1 | High temperature poly(aryl ether)s containing a phthalazinone moiety | HT MATERIALS CORPORATION | 2007-10-11 | — | — | US | disclosed |
| US-20070238853-A1 | High temperature poly(aryl ether)s containing a phthalazinone moiety | HT MATERIALS CORPORATION | 2007-10-11 | — | — | US | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132035-A1 | Toll-Like Receptor 8 (TLR8)-Specific Antagonists and Methods of Making and Uses Thereof | TLR8, TLR3, TLR9 | KDM4E 3389/4885LMNA 3870/4885ALDH1A1 4565/4885 |
| US-20210179621-A1 | Toll-Like Receptor 8 (TLR8) Specific Antagonists and Methods of Making and Uses Thereof | TLR8, TLR3, TLR9 | KDM4E 3431/4885LMNA 3732/4885ALDH1A1 4569/4885 |
| US-11466010-B2 | Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof | TLR8, TLR3, TLR9 | KDM4E 3431/4885LMNA 3732/4885ALDH1A1 4569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.