Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496926 | 1.00 | PIK3CD (0.55) | PIK3CDPIK3CAHSD17B1HSD17B2MAP4K4 | |
| SCHEMBL29377935 | 0.85 | NPC1 (0.61) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL25677401 | 0.82 | MAP4K4 (0.52) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL18311414 | 0.80 | CA12 (0.55) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL32667946 | 0.79 | PDGFRB (0.77) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL2772360 | 0.79 | PDGFRB (0.77) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8370258 | 0.78 | PDGFRB (0.66) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL3003119 | 0.78 | ESR2 (0.71) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL23555381 | 0.78 | PDGFRB (0.66) | PIK3CDPIK3CAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL14417402 | 0.78 | HSD17B1 (0.58) | PIK3CDPIK3CAHSD17B1HSD17B2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | claimed |
| CN-117586191-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-117586108-A | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2024-02-23 | — | — | CN | disclosed |
| CN-111542515-B | TOLL-like receptor 8 (TLR 8) specific antagonists, methods of making and uses thereof | 科罗拉多州立大学董事会法人团体 | 2023-12-05 | — | — | CN | disclosed |