Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.70 |
| ▸ | ITK | Q08881 | 1/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172510 | 1.00 | LRRK2 (0.70) | LRRK2ITKCYP11B1CYP11B2ABL1 | |
| SCHEMBL29172536 | 0.90 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL30725856 | 0.90 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL30725877 | 0.87 | CDK7 (0.67) | LRRK2ITK | |
| SCHEMBL29172495 | 0.87 | CDK7 (0.67) | LRRK2ITK | |
| SCHEMBL30725869 | 0.86 | LRRK2 (0.58) | LRRK2ITK | |
| SCHEMBL30725858 | 0.86 | DYRK1A (0.61) | LRRK2ITKCYP11B1CYP11B2ABL1 | |
| SCHEMBL29172502 | 0.86 | DYRK1A (0.61) | LRRK2ITKCYP11B1CYP11B2ABL1 | |
| SCHEMBL29172497 | 0.86 | LRRK2 (0.58) | LRRK2ITK | |
| SCHEMBL22890022 | 0.83 | LRRK2 (1.00) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117186066-A | Indazole ALK5 inhibitor and preparation method and application thereof | 中国药科大学 | 2023-12-08 | — | — | CN | disclosed |