Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31044800 | 0.78 | HRH3 (0.47) | RETDRD2DRD4DRD3DRD1 | |
| SCHEMBL23178452 | 0.76 | RET (0.53) | RET | |
| SCHEMBL30175296 | 0.75 | RET (0.45) | RET | |
| SCHEMBL30175294 | 0.75 | RET (0.43) | RETDRD2DRD4DRD3DRD1 | |
| SCHEMBL30175349 | 0.75 | CYP11B1 (0.41) | RETDRD2DRD4DRD3DRD1 | |
| SCHEMBL29759418 | 0.75 | MAP2K1 (0.51) | RETHRH3 | |
| SCHEMBL30175367 | 0.74 | RET (0.48) | RET | |
| SCHEMBL30533091 | 0.73 | RET (0.35) | RETDRD2DRD4DRD3DRD1 | |
| SCHEMBL25252185 | 0.72 | CDK2 (0.36) | RETDRD2DRD4DRD3DRD1 | |
| SCHEMBL30175370 | 0.72 | CDK2 (0.36) | RETDRD2DRD4DRD3DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112574235-B | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业股份有限公司 | 2024-01-16 | — | — | CN | disclosed |