Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 9/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.49 |
| ▸ | HTR3A | P46098 | 3/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039529 | 1.00 | DDB1 (0.49) | DDB1CRBNHTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL30969032 | 0.99 | DDB1 (0.48) | DDB1CRBNHTR3AHTR3EHTR3B | |
| SCHEMBL27039567 | 0.90 | DDB1 (0.56) | DDB1CRBNHTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL30969010 | 0.88 | DDB1 (0.55) | DDB1CRBNHTR3AHTR3EHTR3B | |
| SCHEMBL31437046 | 0.84 | CRBN (0.49) | DDB1CRBNDRD2DRD4DRD3 | |
| SCHEMBL24207745 | 0.83 | DDB1 (0.43) | DDB1CRBNFLT3 | |
| SCHEMBL24207292 | 0.82 | CRBN (0.44) | DDB1CRBN | |
| SCHEMBL31306692 | 0.82 | DDB1 (0.56) | DDB1CRBNHTR3AHTR3EHTR3B | |
| SCHEMBL31437047 | 0.81 | DDB1 (0.46) | DDB1CRBN | |
| SCHEMBL31444019 | 0.80 | CRBN (0.45) | DDB1CRBNDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558495-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | Bristol-Myers Squibb Company (US) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024020084-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-25 | — | — | WO | disclosed |