Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562841 | 0.85 | HPSE (0.60) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL25734944 | 0.83 | HPSE (0.50) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL1561845 | 0.81 | HPSE (0.53) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL6234424 | 0.81 | HPSE (0.52) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL905783 | 0.80 | HPSE (0.64) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL10098857 | 0.79 | ALDH1A1 (0.51) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL18493192 | 0.79 | HPSE (0.50) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL19649562 | 0.78 | HPSE (0.53) | HPSEALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL1562499 | 0.78 | ALDH1A1 (0.54) | HPSEALDH1A1HSD17B10ALOX15TP53 | |
| SCHEMBL5651138 | 0.78 | HPSE (0.50) | HPSEALDH1A1KMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795255-B2 | Rigidified compounds for modulating heparanase activity | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2010-09-14 | — | — | US | claimed |
| US-7795255-B2 | Rigidified compounds for modulating heparanase activity | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2010-09-14 | — | — | US | disclosed |
| US-20080039456-A1 | Rigidified Compounds for Modulating Heparanase Activity | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2008-02-14 | — | — | US | disclosed |
| EP-1846383-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | Insight Biopharmaceuticals Ltd. (IL) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006072953-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039456-A1 | Rigidified Compounds for Modulating Heparanase Activity | HPSE, HEXA, GAA | HPSE 1/4885ALDH1A1 2428/4885KMT2A 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.