Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3062815 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KCNN4CACNA1FCACNA1DCACNA1S | |
| SCHEMBL580798 | 1.00 | ALDH1A1 (0.49) | ALDH1A1KCNN4CACNA1FCACNA1DCACNA1S | |
| SCHEMBL581795 | 0.96 | ALDH1A1 (0.47) | ALDH1A1KCNN4CACNA1FCACNA1DCACNA1S | |
| SCHEMBL581796 | 0.96 | ALDH1A1 (0.47) | ALDH1A1KCNN4CACNA1FCACNA1DCACNA1S | |
| SCHEMBL581242 | 0.92 | ALDH1A1 (0.40) | ALDH1A1KCNN4KMT2ATRPV4 | |
| SCHEMBL3081049 | 0.89 | ALDH1A1 (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2GAA | |
| SCHEMBL581482 | 0.89 | ALDH1A1 (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2GAA | |
| SCHEMBL3075881 | 0.89 | ALDH1A1 (0.39) | ALDH1A1POLBMAPK1SMN1; SMN2GAA | |
| SCHEMBL587487 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KCNN4KMT2ATRPV4 | |
| SCHEMBL582518 | 0.88 | TACR1 (0.42) | ALDH1A1LMNAUSP2MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415378-B2 | Isoxazol-3(2H)-one analogs as therapeutic agents | ASTRAZENECA AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | NR4A3, CBR3, OXER1 | ALDH1A1 2598/4885KCNN4 171/4885CACNA1F 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.